Author:
Edition: 1
Publisher: Wiley
Binding: Hardcover
ISBN: 0470861231
Statistical Methods for Dose-Finding Experiments (Statistics in Practice)
Dose-finding experiments define the safe dosage of a drug in development, in terms of the quantity given to a patient. Medical books Statistical Methods for Dose-Finding Experiments . Statistical methods play a crucial role in identifying optimal dosage. Used appropriately, these methods provide reliable results and reduce trial duration and costs. In practice, however, dose-finding is often done poorly, with widely used conventional methods frequently being unreliable, leading to inaccurate results. However, there have been many advances in recent years, with new statistical techniques being developed and it is important that these new techniques are utilized correctly Medical books Statistical Methods For Dose-Finding Experiments. Dose-finding Experiments define the safe dosage of a Drug in development, in terms of the quantity giSearch butors. Preface. Introduction (Sylvie Chevret). Part I. General Principles and Controversial Issues in Dose-Findings. 1. Basic concepts in dose-fin
Download link for Statistical Methods For Dose-finding Experiments
Dose-finding Experiments define the safe dosage of a Drug in development, in terms of the quantity giSearch butors. Preface. Introduction (Sylvie Chevret). Part I. General Principles and Controversial Issues in Dose-Findings. 1. Basic concepts in dose-fin
Dose-finding experiments define the safe dosage of a drug in development, in terms of the quantity given to a patient. Statistical methods play a crucial role in identifying optimal dosage. Used appropriately, these methods provide reliable results and reduce trial duration and costs. In practice, however, dose-finding is often done poorly, with widely used conventional methods frequently being unreliable, leading to inaccurate results. However, there have been many advances in recent years, with new statistical techniques being developed and it is important that these new techniques are utili
Categories: Statistics->Methods, Drug Compounding->statistics & numerical data, Dose-response relationship, Drug. Contributors: Sylvie Chevret - Author. Format: Hardcover
Categories: Statistics->Methods, Drug Compounding->statistics & numerical data. Contributors: Sylvie Chevret - Author. Format: Hardcover
Medical Book Statistical Methods for Dose-Finding Experiments
Statistical methods play a crucial role in identifying optimal dosage. Used appropriately, these methods provide reliable results and reduce trial duration and costs. In practice, however, dose-finding is often done poorly, with widely used conventional methods frequently being unreliable, leading to inaccurate results. However, there have been many advances in recent years, with new statistical techniques being developed and it is important that these new techniques are utilized correctly. Statistical Methods for Dose-Finding Experiments reviews the main statistical approaches for dose-finding in phase I/II clinical trials and presents practical guidance on their correct use.
- Includes an introductory section, summarizing the essential concepts in dose-finding.
- Contains a section on algorithm-based approaches, such as the traditional 3+3 design, and a section on model-based approaches, such as the continual reassessment method.
- Explains fundamental issues, such as how to stop trials early and how to cope with delayed or ordinal outcomes.
- Discusses in detail the main websites and software used to implement the methods.
- Features numerous worked examples making use of real data.
Statistical Methods for Dose-Finding Experiments is an important collaboration from the leading experts in the area. Primarily aimed at statisticians and clinicians working in clinical trials and medical research, there is also much to benefit graduate students of biostatistics.
