Author:
Edition: 1st Edition.
Publisher: Royal Society of Chemistry
Binding: Hardcover
ISBN: 1849731268
Accounts in Drug Discovery: Case Studies in Medicinal Chemistry (RSC Drug Discovery)
Accounts in Drug Discovery describes recent case studies in medicinal chemistry with a particular emphasis on how the inevitable problems that arise during any project can be surmounted or overcome. Medical books Accounts in Drug Discovery. The Editors cover a wide range of therapeutic areas and medicinal chemistry strategies, including lead optimization starting from high throughput screening "hits" as well as rational, structure-based design. The chapters include "follow-ons" and "next generation" compounds that aim to improve upon first generation agents. This volume surveys the range of challenges commonly faced by medicinal chemistry researchers, including the optimization of metabolism and pharmacokinetics, toxicology, pharmaceutics and pharmacology, including proof of concept in the clinic for novel biological targets. The case studies include medicinal chemistry stories on recently approved and marketed drugs, but also chronicle "near-misses", i Medical books Accounts In Drug Discovery By Joel Barrish. TheNile.com.au About FAQ Payment Delivery Contact Us 1800-987-323 Accounts in Drug Discovery (English) by Joel Barrish Format Hardcover Condition Brand New Language English Accounts in Drug Discovery describes recent case studies in medicinal chemistry with a particular emphasis on how the inevitable problems that arise during any project can be surmounted or overcome. Publisher Description Accounts in Drug Discovery describes recent case studies in medicinal chemistry with a particular emphasi
The Editors cover a wide range of therapeutic areas and medicinal chemistry strategies, including lead optimization starting from high throughput screening "hits" as well as rational, structure-based design. The chapters include "follow-ons" and "next generation" compounds that aim to improve upon first generation agents. This volume surveys the range of challenges commonly faced by medicinal chemistry researchers, including the optimization of metabolism and pharmacokinetics, toxicology, pharmaceutics and pharmacology, including proof of concept in the clinic for novel biological targets. The case studies include medicinal chemistry stories on recently approved and marketed drugs, but also chronicle "near-misses", i.e., exemplary compounds that may have proceeded well into the clinic but for various reasons did not result in a successful registration. As the vast majority of projects fail prior to registration, much can be learned from such narratives. By sharing a wide range of drug discovery experiences and information across the community of medicinal chemists in both industry and academia, we believe that these accounts will provide insights into the art of medicinal chemistry as it is currently practiced and will help to serve the needs of active medicinal chemists.
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TheNile.com.au About FAQ Payment Delivery Contact Us 1800-987-323 Accounts in Drug Discovery (English) by Joel Barrish Format Hardcover Condition Brand New Language English Accounts in Drug Discovery describes recent case studies in medicinal chemistry with a particular emphasis on how the inevitable problems that arise during any project can be surmounted or overcome. Publisher Description Accounts in Drug Discovery describes recent case studies in medicinal chemistry with a particular emphasi
Accounts in Drug Discovery
Accounts in Drug Discovery describes recent case studies in drug discovery and in particular how problems were overcome. In particular, the case studies were selected to cover a broad range of topics including: diverse disease areas (oncology, cardiovascular, metabolic disorders, inflammation, anti-infective agents, GI and urinary disorders); first-in-class vs. follow on compounds; leads compounds that were derived from multiple sources including screening, structure-based design, and follow-ons; successful marketed drugs as well as those that failed prior to or at registration that are rarely
Accounts in Drug Discovery describes recent case studies in drug discovery and in particular how problems were overcome. In particular, the case studies were selected to cover a broad range of topics including: diverse disease areas (oncology, cardiovascular, metabolic disorders, inflammation, anti-infective agents, GI and urinary disorders); first-in-class vs. follow on compounds; leads compounds that were derived from multiple sources including screening, structure-based design, and follow-ons; successful marketed drugs as well as those that failed prior to or at registration that are rarely
Medical Book Accounts in Drug Discovery
The Editors cover a wide range of therapeutic areas and medicinal chemistry strategies, including lead optimization starting from high throughput screening "hits" as well as rational, structure-based design. The chapters include "follow-ons" and "next generation" compounds that aim to improve upon first generation agents. This volume surveys the range of challenges commonly faced by medicinal chemistry researchers, including the optimization of metabolism and pharmacokinetics, toxicology, pharmaceutics and pharmacology, including proof of concept in the clinic for novel biological targets. The case studies include medicinal chemistry stories on recently approved and marketed drugs, but also chronicle "near-misses", i.e., exemplary compounds that may have proceeded well into the clinic but for various reasons did not result in a successful registration. As the vast majority of projects fail prior to registration, much can be learned from such narratives. By sharing a wide range of drug discovery experiences and information across the community of medicinal chemists in both industry and academia, we believe that these accounts will provide insights into the art of medicinal chemistry as it is currently practiced and will help to serve the needs of active medicinal chemists.
