Author:
Edition: 1
Publisher: Cold Spring Harbor Laboratory
Binding: Paperback
ISBN: 1936113554
NF-kB, A Network Hub Controlling Immunity, Inflammation and Cancer
NF-kB is a critical signaling molecule in the immune system that regulates cell survival and cell death, lymphocyte responses, and inflammation. Medical books NF-kB, A Network Hub Controlling Immunity, Inflammation and Cancer. Acting as a transcription factor that can receive several inputs, it coordinates distinct gene expression programs in response to a wide variety of stimuli. Written and edited by experts in the field, this volume includes contributions covering the structure of NF-kB, its DNA-binding activity and specificity, the role of the inhibitor I-B, and canonical and alternative mechanisms of NF-kB activation. The contributors examine the physiological role of NF-kB in immune cells, as well as its functions in other tissues, such as the nervous system. They also discuss work indicating that NF-kB represents a critical link between inflammation and cancer Medical books Nf-Kb, a Network Hub Controlling Immunity, Inflammation, and Cancer.
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This vital reference covers the structure of the key cell signaling molecule NF-B, its DNA-binding activity and specificity, the role of the inhibitor I-B, canonical and alternative mechanisms of NDiscovering NF-kBDavid BaltimoreThe NF-kB Family of Transcription Factors and Its RegulationAndrea Oeckinghaus and Sankar GhoshSpecification of D
Medical Book NF-kB, A Network Hub Controlling Immunity, Inflammation and Cancer
Acting as a transcription factor that can receive several inputs, it coordinates distinct gene expression programs in response to a wide variety of stimuli. Written and edited by experts in the field, this volume includes contributions covering the structure of NF-kB, its DNA-binding activity and specificity, the role of the inhibitor I-B, and canonical and alternative mechanisms of NF-kB activation. The contributors examine the physiological role of NF-kB in immune cells, as well as its functions in other tissues, such as the nervous system. They also discuss work indicating that NF-kB represents a critical link between inflammation and cancer. Including clinical perspectives on the use of NF-kB inhibitors in cancer therapy and a historical introduction by David Baltimore, in whose lab NF-kB was discovered, this volume is a vital reference for cell and molecular biologists, immunologists, and pathologists interested in regulation of cell function.
