Showing posts with label Phase. Show all posts
Showing posts with label Phase. Show all posts
Friday, November 18, 2011

Regulation of the Acute Phase and Immune Responses

Regulation of the Acute Phase and Immune Responses



Author: Pravinkumar B. Sehgal
Edition:
Publisher: New York Academy of Sciences
Binding: Hardcover
ISBN: 0897665317



Regulation of the Acute Phase and Immune Responses: Interleukin-6 (Annals of the New York Academy of Sciences)


Medical books Regulation of the Acute Phase and Immune Responses. Medical books Genetex - GTX100675 - C/EBP beta antibody, GeneTex (Each (100μl)). The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. [provided by RefSeq] This listing is for Each (100 l) Species Reactivity Human MW (kDa) 36 Host Rabbit Isotype IgG Unit Each (100 l) Application Note Suggested starting dilutions are as follows: WB: 1:500-1:3000, IHC-P: 1:100-1:1000 [suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0)]. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. Immunogen Synthetic peptide contain a sequence corresponding to a region within amino acids 1 and 55 of C/EBP beta Monoclonal/Polyclonal Polyclonal Purification Purified by antigen-affinity chromatography. Storage Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. Storage Instruction Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles. Tested Applications IHC-P, WB

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The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of

Cytokines are synthesized and secreted in the liver by Kupffer cells, and are important for inflammation processes, the non-specific immune response, and probably the destruction and removal of tumour cells. The production of signal substances such as tumour necrosis factor-alpha, interleukin 1 and 6, and interferon alpha/beta is regulated by a complex set of pathways, which can also be modified by cellular mediators, eg prostaglandins, growth factors and cortico-steroids. Signal exchange between different cell types in the liver is important for the synthesis of acute phase proteins, liver fi

Cytokines are synthesized and secreted in the liver by Kupffer cells, and are important for inflammation processes, the non-specific immune response, and probably the destruction and removal of tumour cells. Theproduction of signal substances such as tumour necrosis factor-alpha, interleukin 1 and 6, and interferon alpha/beta is regulated by a complex set of pathways, which can also be modified by cellular mediators, egprostaglandins, growth factors and cortico-steroids. Signal exchange between different cell types in the liver is important for the synthesis of acute phase proteins, liver fibr

DESCRIPTION Adreno-Mend™, provided by Douglas Laboratories®, is a synergistic combination of ten highly valued herbal extracts with adaptogenic properties designed to support healthy, balanced adrenal gland function.† These plant adaptogens include Schisandra chinensis, Bacopa monnieri, Rhodiola rosea, Eleutherococcus senticosus, Magnolia officinalis, Rhemannia glutinosa, Bupleurum falcatum, Panax ginseng, Coleus forskohlii and Withania sominfera. FUNCTIONS The response to chronic stress - first defined as occurring in three stages by Hans Selye as alarm, resistance and exhaustion - typic



Medical Book Regulation of the Acute Phase and Immune Responses





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Monday, June 27, 2011

An Introduction to Statistics in Early Phase Trials Epub

An Introduction to Statistics in Early Phase Trials



Author: Steven Julious
Edition: 1
Publisher: Wiley
Binding: Hardcover
ISBN: 0470059850



An Introduction to Statistics in Early Phase Trials


All new medicines and devices undergo early phase trials to assess, interpret and better understand their efficacy, tolerability and safety. Medical books An Introduction to Statistics in Early Phase Trials. An Introduction to Statistics in Early Phase Trials describes the practical design and analysis of these important early phase clinical trials and provides the crucial statistical basis for their interpretation. It clearly and concisely provides an overview of the most common types of trials undertaken in early phase clinical research and explains the different methodologies used. The impact of statistical technologies on clinical development and the statistical and methodological basis for making clinical and investment decisions are also explained.

  • Conveys key ideas in a concise manner understandable by non-statisticians
  • Explains how to optimise designs in a constrained or fixed resource setting
  • Discusses decision making criteria at the end of Phase II trials
  • Highlights practical day-to-day issues and reporting of early phase trials

An Introduction to Statistics in Early Phase Trials is an essential guide for all researchers working in early phase clinical trial development, from clinical pharmacologists and pharmacokineticists through to clinical investigators and medical statisticians Medical books An Introduction to Statistics in Early Phase Trials, 9780470059852. An Introduction to Statistics in Early Phase Trials, ISBN-13: 9780470059852, ISBN-10: 0470059850

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An Introduction to Statistics in Early Phase Trials, ISBN-13: 9780470059852, ISBN-10: 0470059850

Presents an overview of the some of the most common types of trial undertaken in early clinical development. This title describes how information at the end of early phase development can be brought together to facilitate and enhance decisions pertinent to a clinical development programme.

Categories: Biometry->Methods, Drugs->Testing->Statistical methods. Contributors: Steven Julious - Author. Format: Hardcover

Categories: Biometry->Methods, Drugs->Testing->Statistical methods. Contributors: Steven Julious - Author. Format: Hardcover



Medical Book An Introduction to Statistics in Early Phase Trials



An Introduction to Statistics in Early Phase Trials describes the practical design and analysis of these important early phase clinical trials and provides the crucial statistical basis for their interpretation. It clearly and concisely provides an overview of the most common types of trials undertaken in early phase clinical research and explains the different methodologies used. The impact of statistical technologies on clinical development and the statistical and methodological basis for making clinical and investment decisions are also explained.

  • Conveys key ideas in a concise manner understandable by non-statisticians
  • Explains how to optimise designs in a constrained or fixed resource setting
  • Discusses decision making criteria at the end of Phase II trials
  • Highlights practical day-to-day issues and reporting of early phase trials

An Introduction to Statistics in Early Phase Trials is an essential guide for all researchers working in early phase clinical trial development, from clinical pharmacologists and pharmacokineticists through to clinical investigators and medical statisticians. It is also a valuable reference for teachers and students of pharmaceutical medicine learning about the design and analysis of clinical trials.

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